Cooperation between cdlg(leu-llb)+ nk cells and hla-dr+ cells in natural killing of herpesvirus-infected fibroblasts
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Cooperation between cdlg(leu-llb)+ nk cells and hla-dr+ cells in natural killing of herpesvirus-infected fibroblasts
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| Creator |
Hee Oh, Sung
Bandyopadhyay, Santu Miller, Deborah S Start, Stuart E |
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| Subject |
Infectious Diseases and Immunology
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| Description |
We reported previously that natural killer (NK)
cell-mediated lysis of cytomegalovirus-infected targets
requires the presenceo f HLA-DR+ nonadherent
peripheral blood mononuclearc ells (NPBMC). In the
present study we determined whether NK cell-mediated
lysis of other herpesvirus-infected targets
also requires HLA-DR+ cells. Depletion of either
cluster designation (CD)16+ NK cells or HLA-DR+
cells from NPBMC significantly reduced their ability
to lyse herpes simplex virus (HSV)- and varicellazoster
virus (VZV)-infected fibroblasts. When CD16-
and HLA-DR- populations were mixedl,y sis of both
HSV- and VZV-infected targets was virtually completely
restored, indicating thaNt K cells and HLADR+
cells were required for lysis to occur. Cell-free
supernatants, obtained by incubating NPBMC or
CD16- cells with HSV- or VZV-infected targets, contained
antiviral activity and stimulated HLA-DRcells
to mediate lysis of corresponding virus-infected
targets. The addition of anti-interferon-a to
supernatants abolished their ability to stimulate
lysis. Thus, secretion of interferon-a by HLA-DR+
cells contributes to NK cell-mediated lysis of herpesvirus-
infected targets
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| Publisher |
American Association of Immunologists
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| Date |
1987
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1909/1/J._Immunology%2C_139.2799%2D2802._(_8)_;_1987.pdf
Hee Oh, Sung and Bandyopadhyay, Santu and Miller, Deborah S and Start, Stuart E (1987) Cooperation between cdlg(leu-llb)+ nk cells and hla-dr+ cells in natural killing of herpesvirus-infected fibroblasts. The Journal of Immunology, 139 (8). pp. 2799-2802. ISSN 0022-1767 |
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| Relation |
http://www.eprints.iicb.res.in/1909/
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