Vibrio cholerae O395 Outer Membrane Vesicles Modulate Intestinal Epithelial Cells in a NOD1 Protein-dependent Manner and Induce Dendritic Cell-mediated Th2/Th17 Cell Responses
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Vibrio cholerae O395 Outer Membrane Vesicles Modulate
Intestinal Epithelial Cells in a NOD1 Protein-dependent
Manner and Induce Dendritic Cell-mediated Th2/Th17 Cell
Responses
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| Creator |
Chatterjee, Debashree
Chaudhuri, Keya |
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| Subject |
Molecular & Human Genetics
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| Description |
Vibrio cholerae, the etiologic agent of cholera, secretes outer membrane vesicles (OMVs) that are internalized
into host cells. OMVs activate an inflammatory response in intestinal epithelial cells (ECs) via a NOD1-dependent pathway thatactivates dendritic cells (DCs) and promotes T cell polarization toward Th2/Th17 responses.
OMVs stimulate EC-DC cross-talk in generating an inflammatory response.Findings are important for the development of efficient vaccine strategies with OMVs
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| Publisher |
American Society for Biochemistry and Molecular Biology
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| Date |
2013
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1928/1/JOURNAL_OF_BIOLOGICAL_CHEMISTRY___288__(_6)4299%2D4309;2013[76].pdf
Chatterjee, Debashree and Chaudhuri, Keya (2013) Vibrio cholerae O395 Outer Membrane Vesicles Modulate Intestinal Epithelial Cells in a NOD1 Protein-dependent Manner and Induce Dendritic Cell-mediated Th2/Th17 Cell Responses. The Journal of Biological Chemistry, 288 (6). pp. 4299-4309. |
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| Relation |
http://dx.doi.org/10.1074/jbc.M112.408302
http://www.eprints.iicb.res.in/1928/ |
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