Wnt/�-Catenin Pathway Is Regulated by PITX2 Homeodomain Protein and Thus Contributes to the Proliferation of Human Ovarian Adenocarcinoma Cell, SKOV-3
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Wnt/�-Catenin Pathway Is Regulated by PITX2
Homeodomain Protein and Thus Contributes to the
Proliferation of Human Ovarian Adenocarcinoma Cell,
SKOV-3
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| Creator |
Basu, Moitri
Roy, Sib Sankar |
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| Subject |
Cell Biology & Physiology
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| Description |
Wnt pathway and homeodomain proteins are associated with cancer, but their interaction in ovarian cancer
cells has not been studied.PITX2 itself and through inducing Wnt ligands activates the canonical Wnt pathway and cell proliferation. Downregulation
of Frizzled receptors limits further Wnt activation.PITX2 enhances proliferation of SKOV-3 cells by inducing canonical Wnt signaling. This study will help understand the mechanism of proliferation in ovarian cancer cells.
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| Publisher |
American Society for Biochemistry and Molecular Biology
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| Date |
2013
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1930/1/JOURNAL_OF_BIOLOGICAL_CHEMISTRY___288(_6)_4355%2D4367;2013[77].pdf
Basu, Moitri and Roy, Sib Sankar (2013) Wnt/�-Catenin Pathway Is Regulated by PITX2 Homeodomain Protein and Thus Contributes to the Proliferation of Human Ovarian Adenocarcinoma Cell, SKOV-3. The Journal of Biological Chemistry, 288 (6). 4355 -4367. |
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| Relation |
http://dx.doi.org/10.1074/jbc.M112.409102
http://www.eprints.iicb.res.in/1930/ |
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