2-Methoxy-5-methylphenyl thiosemicarbazide: A versatile molecule for the synthesis of thiadiazoles and imidazolinones possessing multiple biological activities
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Creator |
Hirpara, S B
Parikh, K A Merja, B C Parekh, H H |
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| Date |
2013-10-07T07:00:57Z
2013-10-07T07:00:57Z 2003-05 |
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| Identifier |
0975-0983(Online); 0376-4699(Print)
http://hdl.handle.net/123456789/21605 |
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| Description |
1172-1175
Thiosemicarbazide <b>1</b> has been prepared by the reaction of 2-methoxy-5-methyl aniline, ammonia and carbon disulphide with ethanol (95%) and sodium chloroacetate, followed by addition of hydrazine hydrate, which on cyclisation with different aromatic carboxylic acids and substituted azlactones in pyridine furnish the corresponding 2-aryl-5-(2 '-methoxy-5'-methylphenyl amino)- 1,3,4-thiadiazoles <b>2a-o</b> and 2-phenyl- 4-arylidene-1-(2'-methoxy- 5'-methylphenyl thiourido)-5-oxo-imidazolines <b>3a-o</b>. All the compounds have been characterised by elemental analyses, IR, <sup>1</sup>H NMR and Mass spectral data. All the compounds have been evaluated <i>in</i> <i>vitro </i>for their antimicrobial activity against several microbes and antitubercular activity against <i>Mycobacterium tuberculosis</i> <i>H</i><sub>37</sub><i>Rv </i>and anticancer activity. Two compounds are found to be active in anticancer assay. |
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| Language |
en_US
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| Publisher |
NISCAIR-CSIR, India
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Source |
IJC-B Vol.42B(05) [May 2003]
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| Title |
2-Methoxy-5-methylphenyl thiosemicarbazide: A versatile molecule for the synthesis of thiadiazoles and imidazolinones possessing multiple biological activities
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| Type |
Article
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