2-(Quinolin-4-ylthio)-1,3,4-oxadiazole derivatives: Design, synthesis, antibacterial and antifungal studies
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Creator |
Modh, Rahul P
Shah, Dhruvin Chikhalia, Kishor H |
|
| Date |
2013-10-10T11:31:43Z
2013-10-10T11:31:43Z 2013-10 |
|
| Identifier |
0975-0983(Online); 0376-4699(Print)
http://hdl.handle.net/123456789/21840 |
|
| Description |
1318-1324
A series of novel <span style="mso-bidi-font-weight: bold">hybrid 2-(7-chloroquinolin-4-ylthio)-5-(substituted)-1,3,4-oxadiazole<span style="mso-bidi-font-weight:bold"> derivatives have been designed, synthesized which contains different pharmacophores like quinoline and 1,3,4-oxadiazole linked via sulfur atom. All the newly synthesized derivatives have been characterized by IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR spectral and elemental analysis. Further, All the final synthesized scaffolds have been subjected to <i style="mso-bidi-font-style:normal">in vitro </i>antimicrobial activity against several bacteria (<i style="mso-bidi-font-style:normal"><span style="mso-bidi-font-weight:bold">E.coli</span></i><span style="mso-bidi-font-weight: bold">,<i style="mso-bidi-font-style:normal"> P.aeruginosa</i>,<i style="mso-bidi-font-style:normal"><span style="mso-bidi-font-weight:bold"> S.aureus</span></i>,<i style="mso-bidi-font-style:normal"><span style="mso-bidi-font-weight:bold"> S.pyogenus</span></i>) and fungi (<i style="mso-bidi-font-style:normal"><span style="mso-bidi-font-weight:bold">C.albicans</span></i><span style="mso-bidi-font-weight:bold">,<i style="mso-bidi-font-style:normal"> A.niger</i>,<i style="mso-bidi-font-style:normal"> A.clavatus</i>) using broth dilution technique. Among the compounds tested, compounds <b style="mso-bidi-font-weight:normal">3f</b> substituted with coumarin analogue and <b style="mso-bidi-font-weight:normal">3b</b> with amine group at second position of phenyl to oxadiazole moiety are found to be most potent. </span></span></span></span> |
|
| Language |
en_US
|
|
| Publisher |
NISCAIR-CSIR, India
|
|
| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
|
|
| Source |
IJC-B Vol.52B(10) [October 2013]
|
|
| Subject |
Quinoline
1,3,4-oxadiazole Antibacterial Antifungal |
|
| Title |
2-(Quinolin-4-ylthio)-1,3,4-oxadiazole derivatives: Design, synthesis, antibacterial and antifungal studies
|
|
| Type |
Article
|
|