Regio- and Stereoselective Synthesis of a Library of Bioactive Dispiro-Oxindolo/Acenaphthoquino Andrographolides via 1,3- Dipolar Cycloaddition Reaction Under Microwave Irradiation
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Regio- and Stereoselective Synthesis of a Library of Bioactive Dispiro-Oxindolo/Acenaphthoquino Andrographolides via 1,3- Dipolar Cycloaddition Reaction Under Microwave Irradiation
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| Creator |
Hazra, Abhijit
Bharitkar, Yogesh P. Chakraborty, Debanjana Mondal, Susanta Kumar Singal, Nupur Mondal, Shyamal Maity, Arindam Paira, Rupankar Banerjee, Sukdeb Mondal, Nirup B |
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| Subject |
Chemistry
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| Description |
Dispiro-pyrrolidino/pyrrolizidino fused oxindoles/acenaphthoquinones have
been derived from andrographolide via azomethine ylide cycloaddition to the conjugated
double-bond under microwave (MW) irradiation. The reactions are chemo-, stereo-, and
regioselective in nature. Change in amino acid from sarcosine/N-benzyl glycine to L-proline
changes the regiochemistry. A representative library of 40 compounds along with in vitro
anticancer evaluation is reported
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| Date |
2013
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1957/1/ACS_COMBINATORIAL_SCIENCE__Volume_15(_1)_41%2D48;2013[140].pdf
Hazra, Abhijit and Bharitkar, Yogesh P. and Chakraborty, Debanjana and Mondal, Susanta Kumar and Singal, Nupur and Mondal, Shyamal and Maity, Arindam and Paira, Rupankar and Banerjee, Sukdeb and Mondal, Nirup B (2013) Regio- and Stereoselective Synthesis of a Library of Bioactive Dispiro-Oxindolo/Acenaphthoquino Andrographolides via 1,3- Dipolar Cycloaddition Reaction Under Microwave Irradiation. ACS Combinatorial Science, 15 (1). pp. 41-48. |
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| Relation |
http://dx.doi.org/10.1021/co3001154
http://www.eprints.iicb.res.in/1957/ |
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