Biophysical Studies on the Interaction of Aristololactam- -D-glucosideandDaunomycinwithRibonucleicAcids
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Biophysical Studies on the Interaction of Aristololactam- -D-glucosideandDaunomycinwithRibonucleicAcids
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| Creator |
Das, Abhi
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| Subject |
Chemistry
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| Description |
The sentence “This structure has novel features which are of considerable biological interest” may be one of science’s most famous understatement appeared in April 1953 in the scientific paper in ‘Nature’ where James Watson and Francis Crick presented the unique structure of the Deoxyribonucleic acid-helix (Watson and Crick; 1953). A new understanding of heredity and hereditary diseases was possible once it was determined that DNA consists of two chains twisted around each other, or double helix, of alternating phosphate and sugar groups, and that the two chains are held together by hydrogen bonds between pairs of organic bases— adenine (A) with thymine (T), and guanine (G) with cytosine (C). Modern biotechnology also has its basis in the structural knowledge of DNA. The discovery of the structure of the molecule that carries genetic information from one generation to the other solved the mystery of fundamental living cell. In 1961, Francois Jacob and Jacques Monod demonstrated that the products of certain genes regulated the expression of other genes by acting upon specific sites at the edge of those genes. They also hypothesized the existence of an intermediary between DNA and its protein products, which they called messenger RNA. Between 1961 and 1965, the relationship between the information contained in DNA and the structure of proteins was determined: there is a code, the genetic code, which creates a correspondence between the succession of nucleotides in the DNA sequence and a series of amino acids in proteins. The paradigm that “DNA is transcribed into RNA, which is translated into a protein that exerts a phenotype” has instilled a new notion to important biological discoveries. All cells from bacteria to human express their genetic information from DNA to RNA to protein, a principle so fundamental that is termed as ‘the central dogma of molecular biology’
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| Date |
2013
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1982/1/ABHI_DAS_Soft_Copy.pdf
Das, Abhi (2013) Biophysical Studies on the Interaction of Aristololactam- -D-glucosideandDaunomycinwithRibonucleicAcids. PhD thesis, Jadavpur University. |
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| Relation |
http://www.eprints.iicb.res.in/1982/
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