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Pharmacological studies on mechanisms of aminophylline-induced seizures in rats

IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)


Field	Value

Creator	Ray, Arunabha Gulati, Kavita Anand, Seema Vijayan, V K

Date	2013-11-11T10:48:49Z 2013-11-11T10:48:49Z 2005-10

Identifier	0975-1009 (Online); 0019-5189 (Print) http://hdl.handle.net/123456789/23249

Description	849-853 In the present study, the possible role of free radicals in aminophylline-induced seizures was evaluated in albino rats. Aminophylline (theophylline in ethylenediamine; 50- 300 mg/kg) induced convulsions in rats in a dose-dependent manner, and both incidence of seizure and mortality were maximum at 300 mg/kg. Conventional anti-epileptics, diphenylhydantoin and dizocilpine, as well as adenosine agonists were ineffective in antagonizing these seizures. On the other hand, phosphodiesterase inhibitors, pentoxyphylline and rolipram, showed insignificant seizurogenic effects. Pretreatment with antioxidants (ascorbic acid, alpha-tocopherol, and melatonin) showed differential attenuating effects on aminophylline seizures and lethality. Further, prior administration of 1-buthionine sulfoxamine (BSO, glutathione depletor) and triethyltetramine (TETA, superoxide dismutase inhibitor), precipitated seizures and enhanced lethality in response to subthreshold doses of aminophylline. The present results suggested of the possible involvement of oxidative stress during aminophylline-induced seizures.

Language	en_US

Publisher	NISCAIR-CSIR, India

Rights	<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>

Source	IJEB Vol.43(10) [October 2005]

Subject	Aminophylline Antioxidant Oxidative stress Seizures

Title	Pharmacological studies on mechanisms of aminophylline-induced seizures in rats

Type	Article