A simple and efficient microwave-assisted synthesis of substituted isoindolinone derivatives via ligand-free Pd-catalyzed domino C-C/C-N coupling reaction
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Tyagi, Vikas
Khan, Shahnawa Chauhan, P M S |
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| Date |
2014-04-02T11:37:15Z
2014-04-02T11:37:15Z 2013 |
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| Identifier |
Synlett 2013; 24(5): 645-651
http://hdl.handle.net/123456789/1197 |
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| Description |
We have reported a microwave-assisted ligand-free Pd-catalyzed domino C-C/C-N coupling reaction to construct diverse isoindolinone derivatives using amides and isocyanides as coupling partner. This strategy provides isoindolinone derivatives in moderate to good yield and high stereoselectivity. A broad range of amides has been tolerated and no need of extra dry condition in this reaction protocol, which offered highly diverse products and easy handling of the reaction.
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| Format |
179620 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 8393
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| Subject |
Ligand
Pd-catalyzed Isoindolinone Amides Isocyanides |
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| Title |
A simple and efficient microwave-assisted synthesis of substituted isoindolinone derivatives via ligand-free Pd-catalyzed domino C-C/C-N coupling reaction
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| Type |
Article
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