Quercetin Improves Behavioral Deficiencies, Restores Astrocytes and Microglia, and Reduces Serotonin Metabolism in 3-Nitropropionic Acid-Induced Rat Model of Huntington’s Disease
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Quercetin Improves Behavioral Deficiencies, Restores Astrocytes and Microglia, and Reduces Serotonin Metabolism in
3-Nitropropionic Acid-Induced Rat Model of Huntington’s Disease
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| Creator |
Chakraborty, Joy
Singh, Raghavendra Dutta, Debashis Naskar, Amit Rajamma, Usha Mohanakumar, Kochupurackal P. |
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| Subject |
Cell Biology & Physiology
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| Description |
Huntington’s disease (HD) is an autosomal dominant disorder, for which clinically available drugs offer only symptomatic relief. These prescription drugs are not free of side effects, and the patients usually suffer from anxiety and depression. We investigated quercetin,
a dietary flavonoid with free radical scavenging properties, for its beneficial potential if any, in 3-nitropropionic acid (3-NP)-induced HD in rats where both drugs were administered simultaneously.
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| Date |
2014
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2017/1/CNS_NEUROSCIENCE_%26_THERAPEUTICS__V_20(_1)10%2D19__;2014(34).pdf
Chakraborty, Joy and Singh, Raghavendra and Dutta, Debashis and Naskar, Amit and Rajamma, Usha and Mohanakumar, Kochupurackal P. (2014) Quercetin Improves Behavioral Deficiencies, Restores Astrocytes and Microglia, and Reduces Serotonin Metabolism in 3-Nitropropionic Acid-Induced Rat Model of Huntington’s Disease. CNS Neuroscience & Therapeutics, 20 (1). pp. 10-19. |
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| Relation |
http://dx.doi.org/ 10.1111/cns.12189
http://www.eprints.iicb.res.in/2017/ |
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