Antibacterial and antiviral evaluation of sulfonoquinovosyldiacylglyceride: a glycolipid isolated from Azadirachta indica leaves
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Antibacterial and antiviral evaluation of
sulfonoquinovosyldiacylglyceride: a glycolipid isolated
from Azadirachta indica leaves
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| Creator |
Bharitkar, Y.P.
Bathini, S. Ojha, D. Ghosh, S. Mukherjee, H. Kuotsu, K. Chattopadhyay, D. Mondal, Nirup B |
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| Subject |
Chemistry
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| Description |
Assessment of antibacterial as well as antiherpes virus activity of sulfonoquinovosyldiacylglyceride (SQDG), a glycolipid, isolated from the leaves of Azadirachta indica has been described. Antimicrobial activity was evaluated
against Gram-positive, Gram-negative bacteria and herpes simplex virus. SQDG showed significant inhibitory activity against Salmonella typhi and two isolates of Shigella dysenteriae with MIC values 32 lg ml �1, while three isolates of Salm. typhi, Escherichia coli and Vibrio cholerae were inhibited at 64 lg ml �1 and have shown zone diameter ranging from 6�2 to 12�3 mm. The growth kinetics study of SQDG on Salm. typhi and Sh. dysenteriae revealed that the growths were completely inhibited at their MIC values within 24 h of exposure. Interestingly, SQDG inhibits herpes simplex virus (HSV) type 1 and 2 with the EC50 of 9�1 and 8�5 lg ml �1, compared with acyclovir (2�2 and
2�8 lg ml �1 against HSV-1 and HSV-2). The selectivity index (SI) was found to be 12�4 against HSV-1 and 13�41 with HSV-2. Furthermore, the expression of proinflammatory cytokines of HSV-infected and SQDG-treated macrophages
using ELISA kit revealed that SQDG significantly downregulated the production of TNF-a, IL-1b, IL-12 and IL-6.
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| Publisher |
Blackwell Publishing
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| Date |
2014
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| Type |
Article
PeerReviewed |
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| Relation |
http://dx.doi.org/10.1111/lam.12174
http://www.eprints.iicb.res.in/2025/ |
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| Identifier |
Bharitkar, Y.P. and Bathini, S. and Ojha, D. and Ghosh, S. and Mukherjee, H. and Kuotsu, K. and Chattopadhyay, D. and Mondal, Nirup B (2014) Antibacterial and antiviral evaluation of sulfonoquinovosyldiacylglyceride: a glycolipid isolated from Azadirachta indica leaves. Letters In Applied Microbiology, 58 (2). pp. 184-189. ISSN 0266-8254
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