Application Of 1,3-Dipolar Cycloaddition Reactions In The Synthesis Of Carbohydratebased Spiro-Heterocycles
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Application Of 1,3-Dipolar Cycloaddition Reactions In The Synthesis Of Carbohydratebased Spiro-Heterocycles
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| Creator |
Deb Barman, Piyali
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| Subject |
Chemistry
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| Description |
The thesis embodies the results of studies on the ―APPLICATION OF 1,3-DIPOLAR CYCLOADDITION REACTIONS IN THE SYNTHESIS OF CARBOHYDRATE-BASED SPIROHETEROCYCLES‖. Carbohydrate-based heterocyclic scaffolds are a class of exceedingly popular bioactive natural and synthetic chemical entities featuring carbohydrate containing mono or
polynuclear heterocyclic cores in their skeleton, with broad spectrum of antitumor, antimicrobial and antiviral activities. Some of them have proved their efficacy in the treatment of several deadly diseases like influenza (H1N1), HIV, cancer etc. Hence, it is not surprising that engagement of medicinal chemists for the construction and bio-evaluation of diversely modified newer carbohydratebased
heterocyclic libraries having fused, bridged or spiro linkages, has assumed immense attention in recent times and amongst them, carbohydrate-based spiro- and bisspiropyrrolidine skeletons are well documented. Nevertheless, the diversity of pyrrolidine skeleton as well as their biological and pharmaceutical relevance is still motivating academic and industrial researchers to look for new and improved syntheses for pyrrolidine derivatives. Among several available tools for the realization of
this goal, the 1,3-dipolar azomethine ylide cycloaddition reaction on a properly functionalized carbohydrate derived olefin system caught our attention, as it is a simple and easily accessible one-pot three-component reaction procedure, involving a trouble-free [3+2] cycloaddition reaction.
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| Date |
2014
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2031/1/Piyali_Thesis_Final%2D%2D1.pdf
Deb Barman, Piyali (2014) Application Of 1,3-Dipolar Cycloaddition Reactions In The Synthesis Of Carbohydratebased Spiro-Heterocycles. PhD thesis, Jadavpur University. |
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| Relation |
http://www.eprints.iicb.res.in/2031/
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