Synthesis of 3H-pyrazolo[3,4-c]isoquinolines and thieno[3,2-c]isoquinolines via cascade imination/intramolecular decarboxylative coupling
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Pandey, Garima
Bhowmik, Subhendu Batra, Sanjay |
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| Date |
2014-06-20T07:45:33Z
2014-06-20T07:45:33Z 2013 |
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| Identifier |
Organic Letters, 2013, 15(19), 5044-7
http://hdl.handle.net/123456789/1288 |
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| Description |
A general approach for the synthesis of 3H-pyrazolo[3,4-c]isoquinolines and thieno[3,2-c]isoquinolines is described involving the implementation of a cascade imination/ intramolecular decarboxylative coupling between potassium 2-amino(hetero)benzoates and 2-haloarylaldehydes. The reactions of pyrazole-based substrates require a Pd-Cu bimetallic system for superior yields whereas the thienyl-based substrates afford the products in excellent yields with Pd-catalyst only.
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| Format |
268746 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI communication No. 8542
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| Subject |
Synthesis
3H-pyrazolo[3,4-c]isoquinolines thieno[3,2-c]isoquinolines cascade decarboxylative coupling |
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| Title |
Synthesis of 3H-pyrazolo[3,4-c]isoquinolines and thieno[3,2-c]isoquinolines via cascade imination/intramolecular decarboxylative coupling
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| Type |
Article
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