Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents*
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Sashidhara, K V
Dodda, R P Sonkar, Ravi Palnati, G P Bhatia, Gitika |
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| Date |
2014-07-16T09:32:24Z
2014-07-16T09:32:24Z 2014 |
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| Identifier |
European Journal of Medicinal Chemistry, 2014, 81, 499 -509
http://hdl.handle.net/123456789/1309 |
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| Description |
A series of novel indole-chalcone fibrates were synthesized and their hypolipidemic activity was evaluated in triton WR-1339 induced hyperlipidemic rat model. Preliminary studies indicated that the hybrids 19, 24 and 29 exhibited potent in vitro antioxidant and significant in vivo antidyslipidemic effects. Our results suggest that these new hybrid architectures may serve as promising leads for the development of next generation lipid lowering agents.
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| Format |
753890 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI communication no. 8661
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| Subject |
Indole-Chalcone Fibrates
Antidyslipidemic Activity Triton Model LPL Activity Antioxidant Activity |
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| Title |
Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents*
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| Type |
Article
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