Studies directed towards the synthesis rhizopodin: stereoselective synthesis of the C1-C15 fragment
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Chakraborty, T K
Pulukuri, K K Sreekanth, Midde |
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| Date |
2014-07-21T10:37:41Z
2014-07-21T10:37:41Z 2010 |
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| Identifier |
Tetrahedron Letters 2010, 51(49), 6444 – 6446
http://hdl.handle.net/123456789/1312 |
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| Description |
A stereoselective synthesis of the C1-C15 fragment of a G-actin binding natural macrodiolide, rhizopodin was achieved using, as key steps, highly stereoselective acetate aldol reactions to build the C1-C7 fragment, one pot oxazole synthesis and an asymmetric Keck allylation reaction to build the C8-C15 fragment and finally, a Stille reaction to couple both the fragments.
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| Format |
163015 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 7964
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| Subject |
Rhizopodin
Acetate aldol reaction Keck allylation Stille coupling |
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| Title |
Studies directed towards the synthesis rhizopodin: stereoselective synthesis of the C1-C15 fragment
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| Type |
Article
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