A Biomimetic Approach For Bicyclic Alkaloids Using Acetal Pro-nucleophile: Total Synthesis of (±)-Epilupinine and Formal Syntheses of (±)-Laburnine, (±)-Isoretronecanol (±)-Tashiromine†
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Koley, Dipankar
Srinivas, Kyatham Krishna, Yarkali Gupta, Archita |
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| Date |
2014-07-31T10:24:07Z
2014-07-31T10:24:07Z 2014 |
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| Identifier |
RSC Advances, 2014, 4, 3934-3937
http://hdl.handle.net/123456789/1326 |
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| Description |
A direct Mannich type diastereoselective biomimetic cyclization using acetal as pro-nucleophile leading to the hydroxymethyl substituted bicyclic framework of various bicyclic alkaloids is presented. Following this protocol, total synthesis of (±)-epilupinine and formal syntheses of (±)-laburnine, (±)-isoretronecanol and (±)-tashiromine are described.
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125728 bytes
application/pdf |
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| Language |
es
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| Relation |
CSIR-CDRI Communication No. 8575
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| Subject |
Biomimetic Approach
Bicyclic Alkaloids; Acetal Pro-nucleophile Epilupinine Laburnine Isoretronecanol Tashiromine |
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| Title |
A Biomimetic Approach For Bicyclic Alkaloids Using Acetal Pro-nucleophile: Total Synthesis of (±)-Epilupinine and Formal Syntheses of (±)-Laburnine, (±)-Isoretronecanol (±)-Tashiromine†
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Article
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