Design and synthesis of a new class of 4-aminoquinolinyl- and 9-anilinoacridinyl Schiff base hydrazones as potent antimalarial agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Sharma, Moni
Chauhan, Kuldeep Srivastava, R K Singh, S V Srivastava, Kumkum Saxena, J K Puri, S K Chauhan, P M S |
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| Date |
2014-08-01T11:31:52Z
2014-08-01T11:31:52Z 2014 |
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| Identifier |
Chemical Biology & Drug Design, 2014, 84(2), 175-81
http://hdl.handle.net/123456789/1334 |
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| Description |
A series of novel 4-aminoquinolinyl and 9-anilinoacridinyl Schiff base hydrazones have been synthesized and evaluated for their antimalarial activity. All compounds were evaluated in vitro for their antimalarial activity against chloroquine-sensitive strain 3D7 and the chloroquine-resistant K1 strain of P. falciparum and for cytotoxicity toward Vero cells. Compounds 17, 20, and 21 displayed good activity against the 3D7 strain with IC50 values ranging from 19.69-25.38 nM. Moreover, compounds 16, 17, 21, 24, 32 and 33 exhibited excellent activities (21.64-54.26 nM) against K1 strain and several compounds displayed β-hematin inhibitory activity, suggesting that, they act on the haem crystallization process like CQ. Compounds were also found to be nontoxic with good selectivity index
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234842 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 8600
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| Subject |
4-Aminoquinoline
9-Anilinoacridine Schiff base Oxalamide Antimalaria |
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| Title |
Design and synthesis of a new class of 4-aminoquinolinyl- and 9-anilinoacridinyl Schiff base hydrazones as potent antimalarial agents
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| Type |
Article
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