Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antipasmodial and antimicrobial agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Mishra, Amita
Batchu, Harikrishna Srivastava, Kumkum Singh, Pratiksha Shukla, P K Batra, Sanjay |
|
| Date |
2014-08-04T11:19:35Z
2014-08-04T11:19:35Z 2014 |
|
| Identifier |
Bioorganic & Medicinal Chemistry Letters, 2014, 24(7), 1719-23
http://hdl.handle.net/123456789/1338 |
|
| Description |
Synthesis and bioevaluation of new diaryl ether hybridized quinoline derivatives as antiplasmodial, antibacterial and antifungal agents is reported. It was encouraging to discover that several compounds displayed 2-3 folds better efficacy than chloroquine in chloroquine-resistant K1 strain of P. falciparum. Further, a few members of the library displayed good antibacterial efficacy against gram positive strains of bacteria but none of the compounds displayed any significant antifungal activity.
|
|
| Format |
407430 bytes
application/pdf |
|
| Language |
en
|
|
| Relation |
CSIR-CDRI Communication No. 8620
|
|
| Subject |
Diaryl ether
Quinoline Hybrid Malaria Antibacterial |
|
| Title |
Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antipasmodial and antimicrobial agents
|
|
| Type |
Article
|
|