An improved HPLC method for simultaneous estimation of isocurcumenol, ar-turmerone and α,β-turmerone in hexane soluble fraction of Curcuma longa and its formulations
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Malasoni, Richa
Naqvi, Arshi Srivastava, Akansha Pandey, R R Singh, Artee Chaudhary, Madhuri Paliwal, S K Dwivedi, A K |
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| Date |
2014-08-05T11:32:56Z
2014-08-05T11:32:56Z 2014 |
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| Identifier |
Journal of Biomaterials and Tissue Engineering, 2014, 4(5), 405-410(6)
http://hdl.handle.net/123456789/1346 |
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| Description |
Curcuma longa (C. longa), a perennial herb, is a member of the Zingiberaceae (ginger) family and possesses a wide array of biological activity. Standardized hexane soluble extract of C. longa rhizomes [Herbal Medicament (HM)] had shown very good anti-stroke activity. A validated High Performance Liquid Chromatography (HPLC) analysis method for isocurcumenol, ar-turmerone and α,β-turmerone was developed for estimation of these compounds in different batches of HM oil and capsules. An alternate equation has been developed for the quantification of α,β-turmerone (an unstable major constituent of HM) using calibration curve of ar-turmerone. This method was applied successfully in stability testing, forced degradation studies of ar-turmerone in pure form, bulk HM oil and HM capsule formulation. The results indicated that ar-turmerone was found to be susceptible for oxidative, photolytic and heat conditions.
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423367 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 8632
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| Subject |
Curcuma longa
Isocurcumenol Ar-turmerone α,β-turmerone HPLC |
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| Title |
An improved HPLC method for simultaneous estimation of isocurcumenol, ar-turmerone and α,β-turmerone in hexane soluble fraction of Curcuma longa and its formulations
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| Type |
Article
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