Engineered Nanocrystal Technology: in-vivo fate, targeting and applications in drug delivery
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Pawar, V K
Singh, Yuvraj Meher, J G Gupta, Siddharth Chourasia, M K |
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| Date |
2014-08-11T05:51:17Z
2014-08-11T05:51:17Z 2014 |
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| Identifier |
Journal of Controlled Release. 2014, 183, 51-66
http://hdl.handle.net/123456789/1349 |
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| Description |
Formulation of nanocrystals is a robust approach which can improve delivery of poorly water soluble drugs, a challenge pharmaceutical industry has been facing since long. Large scale production of nanocrystals is done by techniques like precipitation, media milling and, high pressure homogenization. Application of stabilizers along with drying accords nanocrystals long term stability and commercial viability. These can be administered through oral, parenteral, pulmonary, dermal and ocular routes showing their high therapeutic applicability. They serve to target drug molecules in specific regions through size manipulation and surface modification. This review dwells upon the in-vivo fate and varying applications in addition to the facets of drug nanocrystals stated above.
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882789 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 8640
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| Subject |
Nanocrystals
Poorly Soluble Drugs In-Vivo Fate Bioavailability Stability Targeted Delivery |
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| Title |
Engineered Nanocrystal Technology: in-vivo fate, targeting and applications in drug delivery
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| Type |
Article
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