Deoxysugars as antituberculars and alpha mannosidase inhibitors
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Kashyap, Vivek
Sharma, Smriti Singh, Vinayak Sharma, S K Saquib, Mohammad Srivastava, Ranjana Shaw, A K |
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| Date |
2014-08-11T10:44:26Z
2014-08-11T10:44:26Z 2014 |
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| Identifier |
Antimicrobial Agents Chemotherapy, 2014, 58 (6), 3530-3532
http://hdl.handle.net/123456789/1355 |
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| Description |
A promising modified sugar molecule was identified which was active against MDR strains of Mycobacterium tuberculosis suggesting involvement of a new target. The compound was demonstrated to be bactericidal, inhibited the growth of M. tuberculosis in mice and targeted α-mannosidase as a competitive inhibitor with Ki value of 353.9 µM.
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| Format |
196255 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 8647
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| Subject |
Drug Development
Mycobactericidal Alpha Mannosidase Inhibitor |
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| Title |
Deoxysugars as antituberculars and alpha mannosidase inhibitors
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| Type |
Article
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