Synthesis of novel β-carboline based chalcones with high cytotoxic activity against breast cancer cells
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Chauhan, S S
Singh, A K Meena, Sanjeev Lohani, Minaxi Singh, Akhilesh Arya, R K Cheruvu, S H Sarkar, Jayanta Gayen, J R Datta, Dipak Chauhan, P M S |
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| Date |
2014-08-28T11:55:59Z
2014-08-28T11:55:59Z 2014 |
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| Identifier |
Bioorganic & Medicinal Chemistry Letters, 2014, 24(13):2820-4
http://hdl.handle.net/123456789/1383 |
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| Description |
A series of novel β-carboline based chalcones was synthesized and evaluated for their cytotoxic activity against a panel of human cancer cell lines. Among them we found that two of the compounds 7c and 7d, showed marked anti-proliferative activity in a panel of solid tumor cell lines with highest effect in breast cancer. The compounds 7c and 7d showed an IC50 of 2.25 and 3.29 µM respectively against human breast cancer MCF-7 cell line. Further, the compound 7c markedly induced DNA fragmentation and apoptosis in breast cancer cells.
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511857 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 8690
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| Subject |
Anticancer
β-carboline Chalcone Cytotoxic |
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| Title |
Synthesis of novel β-carboline based chalcones with high cytotoxic activity against breast cancer cells
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| Type |
Article
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