CSIR Central

Disposition of Pharmacologically Active Dietary Isoflavones in Biological Systems

IR@CDRI: CSIR-Central Drug Research Institute, Lucknow


Field	Value

Creator	Wahajuddin Taneja, Isha Arora, Sumit Raju, K S R Siddiqui, Nida

Date	2014-08-28T09:11:11Z 2014-08-28T09:11:11Z 2013

Identifier	Current Drug Metabolism, 2013, 14(4), 369-380 http://hdl.handle.net/123456789/1380

Description	Dietary isoflavones, popularly known as phytoestrogens, represent one of the most biologically active classes of flavonoids. Numerous in vitroandin vivostudies provide convincing evidence regarding their beneficial effects on human health. These isoflavones are increasingly being investigated as potential alternate therapies for a range of hormone-dependent conditions, including cancer, menopausal symptoms, osteoporosis and cardiovascular diseases. However, they exhibit poor oral bioavailability which limits their clinical utility in humans. The reason being, they are substrates of a plethora of enzymes and transporters and undergo extensive conjugative metabolismwhich facilitate their rapid elimination from biological systems. In addition, a number of experimental studies have also revealed that these isoflavones are potent inhibitors of various cytochrome P450 isoforms and transporters which play an important role in the disposition of many commonly prescribed drugs. Thus, there arise chances of observing clinically relevant herb-drug interactions which could sometimes be life-threatening. This review gives a comprehensive understanding of these dietary phytoestrogens with regard to their absorption, biodistribution and the role of enzyme-transporter interplay affecting their disposition in biological systems. Further, the effects of these phytoestrogens on the activity and kinetics of drug metabolizing enzymes and various clinically relevant influx/efflux transporters and the resulting diet-drug interactions have also been discussed.

Format	206885 bytes application/pdf

Language	en

Relation	CSIR-CDRI Communication No. 8436

Subject	Conjugates Disposition Efflux transporters Enteric recirculation Isoflavones Phase II metabolism

Title	Disposition of Pharmacologically Active Dietary Isoflavones in Biological Systems

Type	Article