Synthesis and Biological Evaluation of Chalcones as Potential Antileishmanial Agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Gupta, Shweta
Shivahare, Rahul Korthikunta, Venkateswarlu Singh, Rohit Gupta, Suman Tadigoppula, Narender |
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| Date |
2014-08-29T11:19:22Z
2014-08-29T11:19:22Z 2014 |
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| Identifier |
European Journal of Medicinal Chemistry, 2014, 23, 81, 359-66
http://hdl.handle.net/123456789/1386 |
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| Description |
Antileishmanial activities of thirty five synthetic chalcones have been examined. Among them, ten compounds (4, 6, 16, 22, 23, 24, 25, 29, 35 and 37) exhibited potent in vitro activity (IC50 range from 1.70 to 8 µM) against extracellular promastigotes and intracellular amastigotes form of Leishmania donovani. Two promising compounds 22 and 37 were tested in vivo in L. donovani / hamster model. Chalcone 37 showed 83.32% parasite inhibition at a dose of 50 mg/kg for 10 days whereas, 75.89% parasite inhibition at 100 mg/kg dose for 5 days by intraperitoneal route at day 7 post-treatment.
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293374 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 8693
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| Subject |
Chromenochalcones
Chromenodihydrochalcones Antileishmanial Leishmania donovani / Hamster model |
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| Title |
Synthesis and Biological Evaluation of Chalcones as Potential Antileishmanial Agents
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| Type |
Article
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