Studies on the Synthetic and Medicinal Application of Baylis-Hillman Chemistry
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Singh, Vijay
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| Date |
2014-09-10T06:33:13Z
2014-09-10T06:33:13Z 2008 |
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http://hdl.handle.net/123456789/1398
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| Description |
Guide- Dr. Sanjay Batra, Phd Thesis Submitted to Chhatrapati Shahuji Maharaj University, Kanpur in 2008.
Acquiring the capability to access structurally complex and diverse molecules through simple building blocks has been one of the underlying principles of chemical research. These diverse compounds are desired in order to serve mankind in a variety of ways. With the aim to generate an enormously complex skeletal diversity, chemists are always on the lookout for efficient complexity-generating reactions. One such reaction which has received enormous attention in the recent times is the Baylis-Hillman reaction. Considered to be the youngest of the carbon-carbon bond forming reactions, its propensity to deliver 3-carbon homologation bearing chemoselective functional groups in one step to carry out the synthesis of heterocycles, natural products and synthetic intermediates for the drug candidates has been exploited by several research groups across the globe. It is noteworthy that despite enormous growth appreciable scope still exists to explore the synthetic utility of adducts afforded by this reaction. This endeavour is an attempt in this direction. In particular this dissertation relates to the studies towards the synthesis of cyclic frameworks utilizing the Baylis-Hillman chemistry. The first chapter contains the review of the literature concerning the advancement in the synthesis of cyclic frameworks by the use of derivatives offered by the Baylis-Hillman chemistry. Later in the chapter the basis for initiating these studies has been outlined. The second chapter describes the results of the studies related to the synthesis of heterocycles from the intermediates afforded by the Baylis-Hillman derivatives of substituted isoxazolecarbaldehydes. The third chapter include the studies carried out for the construction of oxygen- and nitrogen-containing heterocyclic systems especially the ones containing the exocyclic methylene group by the use of Baylis-Hillman derivatives of simpler aldehydes. The results related to the biological screening of several compounds generated during the present endeavour are presented in the fourth chapter. Perspectives drawn from the present work and the literature appearing during the period of accomplishment of this work are compiled at last. Most of the novel observations of the present work were published which are listed in the end. Although the chapters have separate bibliography, the compounds mentioned in the chapter two and three are serially numbered in Arabic. The compounds in the review section contain their own numbering in Arabic. |
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3739589 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Thesis No. S-217
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| Subject |
Synthetic
Medicinal Application Baylis-Hillman Chemistry |
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| Title |
Studies on the Synthetic and Medicinal Application of Baylis-Hillman Chemistry
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| Type |
Thesis
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