Base mediated 7-exo-dig intramolecular cyclization of Ugi-Propargyl precursors: Ugi-Propargyl precursors and regioselective synthetic approach toward diverse 1, 4-benzoxazepine-5(2H)-ones
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Pandey, Shashi
Kumar, S V Kant, Ruchir Chauhan, P M S |
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| Date |
2014-09-17T11:10:24Z
2014-09-17T11:10:24Z 2014 |
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| Identifier |
Organic & Biomolecular Chemistry, 2014, 12, 5346-5350
http://hdl.handle.net/123456789/1404 |
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| Description |
A metal-free facile and efficient two-step synthetic protocol for the preparation of 1, 4-benzoxazepine-5(2H)-ones derivatives has been developed. The protocol involves Ugi reaction followed by K2CO3 mediated highly regioselective 7-exo-dig intramolecular cyclization of less-nucleophilic oxygen with the pendant alkyne moiety of Ugi-propargyl precursor to afford the 1, 4-benzoxazepine-5(2H)-one derivatives in good to excellent yields.
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378725 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 8711
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| Subject |
Base Mediated 7-Exo-Dig
Intramolecular Cyclization Ugi-Propargyl Precursors Ugi-Propargyl Precursors Regioselective Synthetic Approach |
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| Title |
Base mediated 7-exo-dig intramolecular cyclization of Ugi-Propargyl precursors: Ugi-Propargyl precursors and regioselective synthetic approach toward diverse 1, 4-benzoxazepine-5(2H)-ones
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Article
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