Evaluation of bioactive components from natural products for prevention of toxicity and neurological disorders
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Evaluation of bioactive components from natural products for prevention of toxicity and neurological disorders
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| Creator |
Bhattacharjee, Payel
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| Subject |
Structural Biology & Bioinformatics
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| Description |
Nature has created almost an inexhaustible array of molecular entities, which stands as
an infinite resource for novel therapeutics and scaffolds for designing of efficacious drugs
for a multitude of diseases. The synthetic products gained attention due to its cost and
time effectiveness, easy quality control, stringent regulation and quick effects, but their
safety and efficacy often remain questionable, resulting in the dependence on the natural
products by more than 80% of the total population in the developing world. This study
deals with the characterization of proteins, peptides and small organic molecules isolated
from natural sources like a medicinal plant Aristolochia indica, Russell’s viper (Daboia
russelli russelli) venom (RVV) and human placental extract towards possible
development of drugs against various illness.
The investigation was initiated on the aqueous extract of the root of A. indica, a wellknown
medicinal plant used against snake envenomation in many parts of rural India.
Our aim was to evaluate the root extract of this ethnomedicine from its biochemical
characters. The aristolochic acid (AA) content of the extract is considerably low and the
solution does not exert any detectable toxicity in animals. It contains a large number of
proteins that appear to be clustered under native condition. It does not show nonspecific
protease activity but strong gelatinolytic, collagenase, nuclease and peroxidase activities.
It interacts with the components of RVV and partially inhibits proteolytic and L-amino
acid oxidase (LAAO) activities of the venom. Collectively, the properties of the extract
explain, at least in parts, neutralization of RVV-induced toxicity and also its application
in wound healing and inflammatory diseases.
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| Date |
2014
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2073/1/Thesis_Final____Payel__Bhattacharjee.pdf
Bhattacharjee, Payel (2014) Evaluation of bioactive components from natural products for prevention of toxicity and neurological disorders. PhD thesis, Jadavpur University. |
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| Relation |
http://www.eprints.iicb.res.in/2073/
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