Studies on the Bioactive Constituents of Azadirachta indica and Shorea robusta
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Studies on the Bioactive Constituents of Azadirachta indica and Shorea robusta
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| Creator |
Pandharinath, Bharitkar Yogesh
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| Subject |
Chemistry
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| Description |
The work embodied in this thesis describes the isolation and structure elucidation of some phytochemical constituents like glycolipids, cerebrosides, flavone glycosides and triterpenoids from Indian medicinal plants Azadirachta indica A. Juss (Neem) and Shorea robusta Gaertner f. (Sal) that are receiving much attention in recent years for their useful biological activities.The chapter I of thesis contains a review on Shorea robusta. A list major classes of compounds triterpenoids, phenolic compounds, volatile oils, steroids and a steroid glycosides so far isolated from different parts of Shorea robusta and pharmacological activities of few extracts and compounds have been presented in this review.Chapter II describes the isolation, purification of phytochemical constituents from mature leaves of Azadirachta indica and characterization by modern spectroscopic technique like IR, ESI-MS, 1H NMR, 13C NMR with DEPT 90 and 135, 2D NMR– COSY, NOESY, HSQC, HMBC. It also describes anti-leukemic activity in human leukemic cell lines U937 and K562 with most active principle; sulfonoquinovosyldiacylglyceride (SQDG). SQDG also shows significant antibacterial as well as anti herpes virus activity. Chapter III of thesis describes the isolation, purification phytochemical constituents from Shorea robusta resin and characterization by modern spectroscopic technique like IR, ESI-MS, 1H NMR, 13C NMR with DEPT 90 and 135. Chapter also deals with spermicidal, microbicidal activity of Asiatic acid.
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| Date |
2013
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2074/1/BHARITKAR_YOGESH.pdf
Pandharinath, Bharitkar Yogesh (2013) Studies on the Bioactive Constituents of Azadirachta indica and Shorea robusta. PhD thesis, Jadavpur University. |
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| Relation |
http://www.eprints.iicb.res.in/2074/
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