Synthesis of Polynuclear Heteroaromatics Using Green Chemistry Protocols and their Bio-Evaluation
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Synthesis of Polynuclear Heteroaromatics Using Green Chemistry Protocols and their Bio-Evaluation
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| Creator |
Banerjee, Maitreyee
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| Subject |
Chemistry
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| Description |
The work embodied in this thesis describes the facile synthesis of nitrogen containing heterocyclic compounds through facile and environment friendly protocol and evaluation of their bioactive potential. Chapter I includes a brief discussion on the development of spermicides from different natural and synthetic sources. The review is a compilation of the promising molecules and even extracts, and includes an outline of the basic physiology behind the bioactivity. Chapter II describes the facile one-pot green methodology to synthesize a series of quinoline derivatives starting from 8-OH-quinoline using di-bromo alkanes as reactant. The synthesized compounds were assessed for their sperm-immobilizing as well as microbicidal activities by various standardized assays. Mode of actions was also investigated by electron microscopic imaging and biochemical assays. Chapter III illustrates the synthesis of 7-Aryl substituted furo[3,2-h]quinoliniums from 5-chloro-8-hydroxy-7-iodo-quinoline in two steps through a tandem Sonogashira alkynylation-cyclization pathway using aryl acetylenes, followed by quaternisation reaction with alkyl halides under microwave irradiation. These compounds too have been screened and investigated for spermicidal activity.Chapter IV narrates the Friedel-Crafts reaction of differently substituted anilines with ninhydrin in presence of molecular iodine at ambient temperature, constituting a facile, cost effective, and regioselective synthesis of a series of 2-mono/2,2-bis-(amino-phenyl)-indane-1,3-dione derivatives. These compounds were screened for Microbicidal activities against quite a few number of bacterial and fungal strains.
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| Date |
2014
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2075/1/Maitreyee_Banerjee%2C_Ph.D._Thesis.pdf
Banerjee, Maitreyee (2014) Synthesis of Polynuclear Heteroaromatics Using Green Chemistry Protocols and their Bio-Evaluation. PhD thesis, Jadavpur University. |
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| Relation |
http://www.eprints.iicb.res.in/2075/
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