Amino Acid and Water-Driven Tunable Green Protocol to Access S-S/C-S Bonds via Aerobic Oxidative Coupling and Hydrothiolation
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Shard, Amit
Kumar, Rajesh Saima Sharma, Nidhi Sinha, A K |
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| Date |
2014-09-29T11:11:11Z
2014-09-29T11:11:11Z 2014 |
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| Identifier |
RSC Advances, 2014, 4(63), 33399-33407
http://hdl.handle.net/123456789/1415 |
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| Description |
A green methodology utilizing natural auxiliary like L-Arginine in conjunction with water and oxygen led to oxidative coupling of thiols into disulfides (S-S bond) whereas thiol-yne coupling (TYC) to access vinyl sulfides (C-S bond) was facilitated in nitrogen atmosphere. The tunable protocol offers several advantages like low catalyst loading, high yields, clean reaction, no over-oxidation of S-S bond besides being metal/base/waste-free. The synthesis of ubiquitous cystine and GSSG in the same catalytic system is an added advantage and the catalytic system has been recycled up to seven times.
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| Format |
348659 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 8722
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| Subject |
Amino acids
Oxidative coupling Vinyl sulfides Waste-free |
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| Title |
Amino Acid and Water-Driven Tunable Green Protocol to Access S-S/C-S Bonds via Aerobic Oxidative Coupling and Hydrothiolation
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| Type |
Article
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