New class of methyl tetrazole based hybrid of (Z)-5-benzylidene-2-(piperazin-1-yl) thiazol-4(%H)-one as potent antitubercular agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Chauhan, Kuldeep
Sharma, Moni Trivedi, Priyanka Chaturvedi, Vinita Chauhan, P. M. S. |
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| Date |
2014-10-27T11:13:11Z
2014-10-27T11:13:11Z 2014 |
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| Identifier |
Bioorganic & Medicinal Chemistry Letters, 2014, 24 (17), 4166–4170
http://hdl.handle.net/123456789/1419 |
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| Description |
In search of potential therapeutics for tuberculosis, we describe here the synthesis and in vitro antitubercular activity of a novel series of thiazolone piperazine tetrazole derivatives. Among all the synthesized derivatives, four compounds (10, 14, 20 and 33) exhibited more potent activity (MIC = 3.08, 3.01, 2.62 and 2.51 μM) than ethambutol (MIC = 9.78 μM) and pyrazinamide (MIC = 101.53 μM) against Mycobacterium tuberculosis. Furthermore, they displayed no toxicity against Vero cells (C1008) and mouse bone marrow derived macrophages (MBMDMɸ). These investigated analogues have emerged as possible lead molecule to enlarge the scope of the study.
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267035 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 8738
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| Subject |
Rhodanine
Tetrazole Mycobacterium tuberculosis Cytotoxicity |
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| Title |
New class of methyl tetrazole based hybrid of (Z)-5-benzylidene-2-(piperazin-1-yl) thiazol-4(%H)-one as potent antitubercular agents
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Article
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