Efficient Stereocontrolled Synthesis of Sitagliptin Phosphate
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Subbaiah, C S
Haq, W |
|
| Date |
2014-11-14T07:16:30Z
2014-11-14T07:16:30Z 2014 |
|
| Identifier |
Tetrahedron: Asymmetry,2014, 25(13–14), 1026–1030
http://hdl.handle.net/123456789/1420 |
|
| Description |
Synthesis of sitagliptin phosphate 1, a novel DPP-IV inhibitor for the treatment of type 2 diabetes mellitus has been accomplished starting from chiral synthon (1,4-bis[(R)-1-phenylethyl]piperazine-2,5-dione) 2, involving high stereocontrolled (>98%) alkylation as a key step, in a good overall yield of 50% over six steps.
|
|
| Format |
232169 bytes
application/pdf |
|
| Language |
en
|
|
| Relation |
CSIR-CDRI Communication No. 8710
|
|
| Subject |
Sitagliptin phosphate
Type 2 diabetes mellitus Stereocontrolled alkylation Asymmetric synthesis |
|
| Title |
Efficient Stereocontrolled Synthesis of Sitagliptin Phosphate
|
|
| Type |
Article
|
|