3,5-Bis(arylmethylene)-4-piperidone derivatives as novel anticancer agents
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Creator |
Jha, Amitabh
Duffield, Katherine M |
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| Date |
2015-03-03T11:51:50Z
2015-03-03T11:51:50Z 2006-10 |
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| Identifier |
0975-0983(Online); 0376-4699(Print)
http://hdl.handle.net/123456789/30750 |
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| Description |
2313-2320
<span style="mso-bidi-language:HI">3,5-Bis(arylmethylene)-4-piperidone derivatives have emerged as novel clusters of cytotoxic agents. The focus <span style="mso-bidi-font-family:Arial;mso-bidi-language:HI">of <span style="mso-bidi-language:HI">the current research has been to tine <span style="mso-bidi-font-family:Arial;mso-bidi-language:HI">tune <span style="mso-bidi-language:HI">the biological activity of these compounds by rational alteration of <span style="mso-bidi-font-family:Arial; mso-bidi-language:HI">substituents <span style="mso-bidi-language:HI">on this <span style="mso-bidi-language:HI">pharmacophore to <span style="mso-bidi-font-family: Arial;mso-bidi-language:HI">increase potency <span style="mso-bidi-language: HI">and selectivity. These compounds arc presumed to bc devoid of <span style="mso-bidi-font-family:Arial;mso-bidi-language:HI">gcnctoxicity <span style="mso-bidi-language:HI">and act <span style="mso-bidi-font-family: Arial;mso-bidi-language:HI">by <span style="mso-bidi-language:HI">selective thiolation of proteins. Anticancer behavior of nine clusters of 3,5-bis(arylmethylene)-4-piperidone derivatives have <span style="mso-bidi-language:HI">been reviewed here with emphasis on their chemistry, cytoxicity and quantitative structure-activity relationship studies. </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span> |
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| Language |
en_US
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| Publisher |
NISCAIR-CSIR, India
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| Relation |
<span style="font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:"Times New Roman"; mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language:HI">Int. Cl.<sup>8 </sup>C07D</span>
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Source |
IJC-B Vol.45B(10) [October 2006]
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| Subject |
Piperidone derivatives
Anticancer agents Cytotoxic Thiolation Topoisomerase II Green chemistry |
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| Title |
3,5-Bis(arylmethylene)-4-piperidone derivatives as novel anticancer agents
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| Type |
Article
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