<span style="font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:Calibri;mso-bidi-font-family:Mangal; mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:HI" lang="EN-US">Characterization and antitubercular activity of synthesized pyrimidine derivatives <i style="mso-bidi-font-style:normal">via</i> chalcones</span>
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Creator |
Faldu, Viral J
Gothalia, Vrajlal K Shah, Viresh H |
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| Date |
2015-03-19T07:06:24Z
2015-03-19T07:06:24Z 2015-03 |
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| Identifier |
0975-0983(Online); 0376-4699(Print)
http://hdl.handle.net/123456789/30951 |
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| Description |
391-398
In the present investigation <i style="mso-bidi-font-style:normal">m</i>-phenoxybenzaldehyde on condensation with various aromatic acetophenone in methanol and 40% aqueous solution of KOH has yielded the corresponding chalcones <b style="mso-bidi-font-weight: normal">4a-h</b><span style="mso-bidi-font-weight:bold">. These chalcones have been further reacted with guanidine hydrochloride, thiourea and urea in the presence of alcoholic KOH, which has led to the formation of pyrimidine derivatives <b style="mso-bidi-font-weight:normal">5a-h</b> to <b style="mso-bidi-font-weight:normal">7a-h</b>. The newly synthesized heterocycles have been characterized on the basis of their chemical properties and spectroscopic data. All novel synthesized derivatives have been screened for their antimycobacterial activities against <i style="mso-bidi-font-style: normal">Mycobacterium tuberculosis</i> H<sub>37</sub>Rv. </span> |
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| Language |
en_US
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| Publisher |
NISCAIR-CSIR, India
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Source |
IJC-B Vol.54B(03) [March 2015]
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| Subject |
Pyrimidine
Antimycobacterial <i><span style="font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:Calibri;mso-bidi-font-family:TimesNewRomanPS-ItalicMT; mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:HI" lang="EN-US">Mycobacterium tuberculosis</span></i> |
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| Title |
<span style="font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:Calibri;mso-bidi-font-family:Mangal; mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:HI" lang="EN-US">Characterization and antitubercular activity of synthesized pyrimidine derivatives <i style="mso-bidi-font-style:normal">via</i> chalcones</span>
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| Type |
Article
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