Microwave assisted three component domino reaction: Synthesis of Indolodiazepinotriazoles
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Arigela, R K
Sharma, S K Kumar, Brijesh Kundu, Bijoy |
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| Date |
2013-04-15T05:35:49Z
2013-04-15T05:35:49Z 2013 |
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| Identifier |
Beilstein Journal of Organic Chemistry 2013, 9, 401–405
http://hdl.handle.net/123456789/1044 |
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| Description |
A microwave assisted three component protocol involving N-1 alkylation of 2-alkynylindoles with epichlorohydrin, ring opening of the epoxide with sodium azide and intramolecular Huisgen azide/internal alkyne 1,3-dipolar cycloaddition domino sequence has been described. The efficacy of the methodology has been demonstrated by treating various 2-alkyl indoles (aromatic/aliphatic) with epichlorohydrin and sodium azide furnishing annulated tetracyclic indolodiazepinotriazoles in satisfactory yields
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| Format |
653473 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 8380
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| Subject |
1, 3-dipolar cycloaddition
domino reaction Azides; 2-alkynyl indoles indolodiazepinotriazoles |
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| Title |
Microwave assisted three component domino reaction: Synthesis of Indolodiazepinotriazoles
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| Type |
Article
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