Engineering of indole-based tethered biheterocyclic alkaloid Meridianin into -carboline derived tetracyclic polyheterocycles via amino functionalization/6-endo cationic π-cyclization.
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Agarwal, P K
Dathi, M D Saifuddin, Mohammad Kundu, Bijoy |
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| Date |
2013-07-22T09:27:57Z
2013-07-22T09:27:57Z 2012 |
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| Identifier |
Beilstein journal of organic chemistry,2012, 8,1901-1908
http://hdl.handle.net/123456789/1113 |
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| Description |
A mild, efficient and versatile method has been developed for the construction of functionalized natural product (Meridianin) and its post conversion to pyrimido-β-carboline using cationic π- cyclization. The strategy involves the introduction of an amino group on the C-5 of the pyrimidine ring and utilising the nucleophilictiy of the C-2 in the indole ring to facilitate cationic π-cyclization.
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| Format |
1015921 bytes
application/pdf |
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| Language |
en
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| Relation |
CSIR-CDRI Communication No. 8330
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| Subject |
Indole
Natural products Meridianin Cyclization Nitrogen Heterocycles |
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| Title |
Engineering of indole-based tethered biheterocyclic alkaloid Meridianin into -carboline derived tetracyclic polyheterocycles via amino functionalization/6-endo cationic π-cyclization.
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| Type |
Article
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