Anti-secretory and cyto-protective effects of Chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Mishra, Vaibhav
Agrawal, Manali Onasanwo, S A Madhur, Gaurav Rastogi, Preeti Pandey, H P Palit, Gautam Narender, Tadigoppula |
|
| Date |
2013-10-08T11:29:28Z
2013-10-08T11:29:28Z 2013 |
|
| Identifier |
Phytomedicine, 2013, 20, (6), 506–511
http://hdl.handle.net/123456789/1133 |
|
| Description |
In continuation of our drug discovery program on Indian medicinal plants, the gastro protective mechanism of chebulinic acid isolated from Terminalia chebula fruit was investigated. Chebulinic acid was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats. Potential anti-ulcer activity of chebulinic acid was observed against CRU (62.9%), AS (55.3%), AL (80.67%) and PL (66.63%) induced ulcer models. The reference drug omeprazole (10mg/kg, p.o.) showed 77.45% protection against CRU, 58.30% against AS and 70.80% against PL model. Sucralfate, another reference drug (500 mg/kg, p.o.) showed 65.67% protection in AL induced ulcer model. Chebulinic acid significantly reduced free acidity (48.82%), total acidity (38.29%) and upregulated mucin secretion by 59.75% respectively. Further, chebulinic acid significantly inhibited H+ K+-ATPase activity in vitro with IC50 of 65.01 µg/ml as compared to the IC50 value of omeprazole (30.24 µg/ml) confirming its anti-secretory activity.
|
|
| Format |
2140610 bytes
application/pdf |
|
| Language |
en
|
|
| Relation |
CSIR- CDRI Communication No. 8396
|
|
| Subject |
Terminalia chebula
Chebulinic Acid Peptic ulcer Proton pump Gastric acid secretion |
|
| Title |
Anti-secretory and cyto-protective effects of Chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers
|
|
| Type |
Article
|
|