Potential of the [99mTc(CO)3(H2O)3] Moiety for the Labeling of Biomolecules for Infection Diagnosis
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Potential of the [99mTc(CO)3(H2O)3] Moiety for the Labeling of Biomolecules for Infection Diagnosis
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| Creator |
Nayak, Dipak Kumar
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| Subject |
Infectious Diseases and Immunology
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| Description |
The research work embodied in this thesis, which has been submitted to the Faculty of Engineering & Technology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, India for the award of degree of Doctor of Philosophy (Pharmacy) has been carried out at the CSIR-Indian Institute of Chemical Biology, Kolkata, under the supervision of Dr. (Mrs.) Mita Chatterjee Debnath, In-Charge Nuclear Medicine Division, Indian Institute of Chemical Biology (CSIR), Kolkata, India & Dr. Tuhinadri Sen, Associate Professor,Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India. Chapter 1 begins with introduction; and a short review of literature. 99mTc(CO)3-ciprofloxacin prepared in high radiochemical yields with substantial stability and better infection imaging agent. These results encouraged us to radiolabel other fluoroquinolones with fac-[99mTc(CO)3(H2O)3] precursor. In an effort to understand the process of radiolabeling with fac-[99mTc(CO)3(H2O)3] precursor better, we have labeled a series of aminocarboxy ligands in Chapter 2. Thereafter we have successfully radiolabel fluoroquinolones in Chapter 3. Similarly thiosemicarbazone complexes with many metals show diverse chemical, physical and biological properties.(N) heterocyclic aldehydes and ketones posses a broad spectrum of potentially useful chemotherapeutic activities e. g. antibacterial, antiviral, antimalarial. The potentially useful biological properties of nitrofuryl thiosemicarbazones as well as outstanding importance of organometallic ion in radiopharmaceuticals chemistry encourage us to radiolabel thiosemicarbazones with 99mTc(CO)3-precursor in Chapter 4.
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| Date |
2014
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2117/1/Dipak_Kumar_Nayak_Thesis.pdf
Nayak, Dipak Kumar (2014) Potential of the [99mTc(CO)3(H2O)3] Moiety for the Labeling of Biomolecules for Infection Diagnosis. PhD thesis, JU. |
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| Relation |
http://www.eprints.iicb.res.in/2117/
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