Antimutagenic and anticancer activity of Darjeeling tea in multiple test systems
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Antimutagenic and anticancer activity of Darjeeling tea in multiple test systems
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| Creator |
Bhattacharya, Udayan
Adak, Shanta Majumder, Niladri Shekhar Bera, Biswajit Giri, Ashok K |
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| Subject |
Molecular & Human Genetics
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| Description |
Darjeeling tea, a most popular variety of black tea, though consumed by the people in different parts of world but its beneficial health effects have not been investigated in details. In this study, the antimutagenic and anticancer effect of Darjeeling tea extract (DTE) has been evaluated.
Antimutagenic activity of the DTE was carried out in two different strains of Salmonella typhimurium by
AMES test against a known mutagen benzo[a]pyrene (B[a]P) with S9 activation. Moreover, anticlastogenic property
of DTE was also measured by micronuclei formation (MN) against B[a]P with S9 activation in human lymphocytes.
The anticancer activity of the same was studied on U937 cell line. Here, Human PBMCs were used as the normal
cell control to identify selective anticancer activity of the extract against U937 cells. The results showed significant antimutagenic activity on bacterial strains. A significant decrease in MN was also observed in the DTE treated human lymphocyte cultures pretreated with B[a]P when compared with B[a]P treated cultures alone. The study clearly exhibited anticancer activity of the extract on U937 cell line. Further studies also revealed that apoptosis induction is an important mechanism behind the anticancer effect of DTE. Overall, this study indicates that DTE has significant antimutagenic and anticancer activities on bacterial and mammalian cells respectively.
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| Publisher |
BioMed Central
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| Date |
2014
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2138/1/BMC_COMPLEMENTARY_AND_ALTERNATIVE_MEDICINE__V_14_Article_Number_327;2014[45].pdf
Bhattacharya, Udayan and Adak, Shanta and Majumder, Niladri Shekhar and Bera, Biswajit and Giri, Ashok K (2014) Antimutagenic and anticancer activity of Darjeeling tea in multiple test systems. BMC Complementary and Alternative Medicine, 14 (327). |
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| Relation |
http://www.eprints.iicb.res.in/2138/
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