CSIR Central

Anomalous altered expressions of downstream gene-targets in TP53-miRNA pathways in head and neck cancer

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata


Field	Value

Title	Anomalous altered expressions of downstream gene-targets in TP53-miRNA pathways in head and neck cancer

Creator	Mitra, Sanga Mukherjee, Nupur Das, Smarajit Das, Pijush K Panda, Chinmay Kumar Chakrabarti, Jayprokas

Subject	Cancer Biology and Inflammatory Disorder Division

Description	The prevalence of head and neck squamous cell carcinoma, HNSCC, continues to grow. Change in the expression of TP53 in HNSCC affects its downstream miRNAs and their gene targets, anomalously altering the expressions of the five genes, MEIS1, AGTR1, DTL, TYMS and BAK1. These expression alterations follow the repression of TP53 that upregulates miRNA-107, miRNA- 215, miRNA-34 b/c and miRNA-125b, but downregulates miRNA-155. The above five so far unreported genes are the targets of these miRNAs. Meta-analyses of microarray and RNA-Seq data followed by qRT-PCR validation unravel these new ones in HNSCC. The regulatory roles of TP53 on miRNA-155 and miRNA-125b differentiate the expressions of AGTR1 and BAK1in HNSCC vis-a`-vis other carcinogenesis. Expression changes alter cell cycle regulation, angiogenic and blood cell formation, and apoptotic modes in affliction. Pathway analyses establish the resulting systems-level functional and mechanistic insights into the etiology of HNSCC.

Date	2014

Type	Article PeerReviewed

Format	application/pdf

Identifier	http://www.eprints.iicb.res.in/2164/1/SCIENTIFIC_REPORTS__V_4_____Article_Number_6280;2014[44].pdf Mitra, Sanga and Mukherjee, Nupur and Das, Smarajit and Das, Pijush K and Panda, Chinmay Kumar and Chakrabarti, Jayprokas (2014) Anomalous altered expressions of downstream gene-targets in TP53-miRNA pathways in head and neck cancer. SCIENTIFIC REPORTS, 4 (6280).

Relation	http://dx.doi.org/10.1038/srep06280 http://www.eprints.iicb.res.in/2164/