Genetically modified organisms and visceral leishmaniasis
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Genetically modified organisms and visceral leishmaniasis
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| Creator |
Chhajer, Rudra
Ali, Nahid |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Vaccination is the most effective method of preventing infectious diseases. Since the eradication of small pox in 1976, many other potentially life compromising if not threatening diseases have been dealt with subsequently.This eventwas a major leap not only in the scientific
world already burdened with many diseases but also in the mindset of the common man who became more receptive to novel treatment options. Among the many protozoan
diseases, the leishmaniases have emerged as one of the largest parasite killers of the world, second only to malaria. There are three types of leishmaniasis namely cutaneous (CL), mucocutaneous (ML), and visceral (VL), caused by a group of more than 20 species of Leishmania parasites.Visceral leishmaniasis, also known as kala-azar is the most severe form and almost fatal if untreated. Since the first attempts at leishmanization,we have killed
parasite vaccines, subunit protein, or DNA vaccines, and now we have live recombinant carrier vaccines and live attenuated parasite vaccines under various stages of development.Although some research has shown promising results, many more potential genes need to be evaluated as live attenuated vaccine candidates. This mini-review attempts to summarize the success and failures of genetically modified organisms used in vaccination
against some of major parasitic diseases for their application in leishmaniasis.
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| Date |
2014
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2168/1/FRONTIERS_IN_IMMUNOLOGY__V_5___Article_Number_213;2014[102].pdf
Chhajer, Rudra and Ali, Nahid (2014) Genetically modified organisms and visceral leishmaniasis. Frontiers in Immunology, 5 (213). |
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| Relation |
http://dx.doi.org/10.3389/fimmu.2014.00213
http://www.eprints.iicb.res.in/2168/ |
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