Flavone-resistant Leishmania donovani Overexpresses LdMRP2 Transporter in the Parasite and Activates Host MRP2 on Macrophages to Circumvent the Flavone-mediated Cell Deat
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Flavone-resistant Leishmania donovani Overexpresses LdMRP2
Transporter in the Parasite and Activates Host MRP2 on
Macrophages to Circumvent the Flavone-mediated Cell Deat
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| Creator |
Chowdhury, Sayan
Mukhopadhyay, Rupkatha Saha, Sourav Mishra, Amartya Sengupta, Souvik Roy, Syamal Majumder, Hemanta K |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Leishmania donovani adopts several defense mechanisms to become resistant to antileishmanial agents. Laboratory-grown flavone (baicalein)-resistant parasites exhibit efflux of drug by LdABCC2 transporter. Inside the host
macrophage, this parasite up-regulates host MRP2 transporter by an Nrf2-dependent pathway. Resistant Leishmania parasite exploits ABC transporter in the parasite and inside the host.
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| Publisher |
American Society for Biochemistry and Molecular Biology
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| Date |
2014
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2174/1/JOURNAL_OF_BIOLOGICAL_CHEMISTRY__V289(_23_)16129%2D16147_;2014[90].pdf
Chowdhury, Sayan and Mukhopadhyay, Rupkatha and Saha, Sourav and Mishra, Amartya and Sengupta, Souvik and Roy, Syamal and Majumder, Hemanta K (2014) Flavone-resistant Leishmania donovani Overexpresses LdMRP2 Transporter in the Parasite and Activates Host MRP2 on Macrophages to Circumvent the Flavone-mediated Cell Deat. The Journal of Biological Chemistry, 289 (23). pp. 16129-16147. |
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| Relation |
http://dx.doi.org/10.1074/jbc.M113.539742
http://www.eprints.iicb.res.in/2174/ |
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