Rational Construction of Triazole/Urea Based Peptidomimetic Macrocycles as Pseudocyclo-β-peptides and Studies on Their Chirality Controlled Self-Assembly
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Rational Construction of Triazole/Urea Based Peptidomimetic
Macrocycles as Pseudocyclo-β-peptides and Studies on Their
Chirality Controlled Self-Assembly
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| Creator |
Ghorai, Abhijit
Reddy K, Samanth Achari, Basudeb Chattopadhyay, Partha |
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| Subject |
Chemistry
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| Description |
A tandem macro-dimerization reaction via a Cu(I)
catalyzed azide/alkyne cycloaddition reaction has been employed to construct triazole/urea based peptidomimetic macrocycles considered as pseudocyclo-β-peptides. Introduction of one particular chirality in the peptide backbone can alter the conformation as well as nature of
self-assembly from cyclic D-,L-,α-peptide to cyclo-β-peptide. One of them (16a) forms antiparallel dimers while the other (16b) undergoes higher order aggregation to form a nanorod structure.
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| Publisher |
American Chemical Society
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| Date |
2014
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2179/1/ORGANIC_LETTERS__V_16_(_12_)3196%2D3199_;2014[88].pdf
Ghorai, Abhijit and Reddy K, Samanth and Achari, Basudeb and Chattopadhyay, Partha (2014) Rational Construction of Triazole/Urea Based Peptidomimetic Macrocycles as Pseudocyclo-β-peptides and Studies on Their Chirality Controlled Self-Assembly. Organic Letters, 16 (12). pp. 3196-3199. |
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| Relation |
http://dx.doi.org/10.1021/ol501172d
http://www.eprints.iicb.res.in/2179/ |
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