Novel Gold(I)− and Gold(III)−N-Heterocyclic Carbene Complexes: Synthesis and Evaluation of Their Anticancer Properties
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Novel Gold(I)− and Gold(III)−N-Heterocyclic Carbene Complexes: Synthesis and Evaluation of Their Anticancer Properties
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| Creator |
Rana, Bidyut Kumar
Nandy, Abhishek Bertolasi, Valerio Bielawski, Christopher W Das Saha, Krishna Dinda, Joydev |
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| Subject |
Cancer Biology and Inflammatory Disorder Division
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| Description |
A novel Au(III)−N-heterocyclic carbene organometallic
complex supported by two N-heterocyclic carbene (NHC)
ligands was synthesized from Au(SMe2)Cl and 1-methyl-2-pyridin-2- yl-2H-imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate via a Ag intermediate. X-ray crystallography revealed the first example of a square planar geometry adopted by a Au(III) species stabilized by two NHCs and two chloride ligands. The aforementioned Au(I)− and Au(III)−NHC complexes were found to be more potent than cisplatin against the HCT 116, HepG2, A549, and MCF7 cell lines.
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| Publisher |
American Chemical Society
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| Date |
2014
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2180/1/ORGANOMETALLICS__V_33_(_10)_2544%2D2548_;2014[100].pdf
Rana, Bidyut Kumar and Nandy, Abhishek and Bertolasi, Valerio and Bielawski, Christopher W and Das Saha, Krishna and Dinda, Joydev (2014) Novel Gold(I)− and Gold(III)−N-Heterocyclic Carbene Complexes: Synthesis and Evaluation of Their Anticancer Properties. Organometallics, 33 (10). pp. 2544-2548. |
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| Relation |
http://dx.doi.org/10.1021/om500118x
http://www.eprints.iicb.res.in/2180/ |
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