Interaction of Ab peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Interaction of Ab peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells
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| Creator |
Saha, Abhijit
Mohapatra, Saswat Kurkute, Prashant Jana, Batakrishna Mondal, Prasenjit Bhunia, Debmalya Ghosh, Subhajit Ghosh, Surajit |
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| Subject |
Chemistry
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| Description |
We report in this work that the Ab peptide directly interacts with tubulin close to the vinblastine and GTP/GDP binding site, inhibits the tubulin polymerization rate, induces tubulin aggregation, causes cell shrinking, enhances Mad2, BubR1, p53, and p21 activation in MCF7
cells and induces the apoptotic death of A549, HeLa and MCF7 cells.
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| Publisher |
Royal Society of Chemistry
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| Date |
2015
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2209/1/CHEMICAL_COMMUNICATIONS__V._51_(_12_)2249%2D2252_;2012[99].pdf
Saha, Abhijit and Mohapatra, Saswat and Kurkute, Prashant and Jana, Batakrishna and Mondal, Prasenjit and Bhunia, Debmalya and Ghosh, Subhajit and Ghosh, Surajit (2015) Interaction of Ab peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells. Chemical Communications, 51 (12). pp. 2249-2252. |
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| Relation |
http://dx.doi.org/10.1039/c4cc09390a
http://www.eprints.iicb.res.in/2209/ |
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