Novel lysosome targeted molecular transporter built on a guanidinium-poly-(propylene imine) hybrid dendron for efficient delivery of doxorubicin into cancer cells
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Novel lysosome targeted molecular transporter
built on a guanidinium-poly-(propylene imine) hybrid dendron for efficient delivery of doxorubicin into cancer cells
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| Creator |
Nair, Jyothi B.
Mohapatra, Saswat Ghosh, Surajit Maiti, Kaustabh K. |
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| Subject |
Chemistry
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| Description |
An efficient synthetic approach has been adopted to construct a new dendron-based octa-guanidine appended molecular transporter with a lysosomal targeted peptide–doxorubicin conjugate. The transporter alone (G8-PPI-FL) is found to be non-toxic, showed higher cellular
uptake compared to Arg-8-mer and exhibited excellent selectivity towards lysosomes in cathepsin B expressing HeLa cells, while the Dox-conjugate showed significant cytotoxicity to cancer cells without affecting the non-cancerous cells.
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| Publisher |
Royal Society of Chemistry
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| Date |
2015
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2210/1/CHEMICAL_COMMUNICATIONS__V._51_(_12_)2403%2D2406___;2015[100].pdf
Nair, Jyothi B. and Mohapatra, Saswat and Ghosh, Surajit and Maiti, Kaustabh K. (2015) Novel lysosome targeted molecular transporter built on a guanidinium-poly-(propylene imine) hybrid dendron for efficient delivery of doxorubicin into cancer cells. Chemical Communications, 51 (12). pp. 2403-2406. |
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| Relation |
http://dx.doi.org/10.1039/c4cc09829c
http://www.eprints.iicb.res.in/2210/ |
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