Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self-DNA
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Cationic antimicrobial peptides in psoriatic skin
cooperate to break innate tolerance to self-DNA
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| Creator |
Lande, Roberto
Chamilos, Georgios Ganguly, Dipyaman Demaria, Olivier Frasca, Loredana Durr, Sophie Conrad, Curdin Schr¨oder, Jens Gilliet, Michel |
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| Subject |
Cancer Biology and Inflammatory Disorder Division
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| Description |
Psoriasis is a T-cell-mediated skin autoimmune disease characterized by the aberrant activation of dermal dendritic cells (DCs) and the sustained epidermal expression of antimicrobial peptides. We have previously identified a link between these two events by showing that the cathelicidin antimicrobial peptide LL37 has the ability to trigger selfnucleic acid mediated activation of plasmacytoid DCs (pDCs) in psoriatic skin. Whether other cationic antimicrobial peptides exert similar activities is unknown. By analysing heparin-binding HPLC fractions of psoriatic scales, we found that human beta-defensin
(hBD)2, hBD3, and lysozyme are additional triggers of pDC activation in psoriatic skin lesions. Like LL37, hBD2, hBD3, and lysozyme are able to condense self-DNA into particles that are endocytosed by pDCs, leading to activation of TLR9. In contrast, other antimicrobial peptides expressed in psoriatic skin including elafin, hBD1, and psoriasin (S100A7) did not show similar activities. hBD2, hBD3, and lysozyme were detected in
psoriatic skin lesions in the vicinity of pDCs and found to cooperate with LL37 to induce high levels of IFN production by pDCs, suggesting their concerted role in the pathogenesis
of psoriasis.
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| Date |
2015
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2215/1/EUROPEAN_JOURNAL_OF_IMMUNOLOGY__V._45__(_1_)_203%2D213;2015[103].pdf
Lande, Roberto and Chamilos, Georgios and Ganguly, Dipyaman and Demaria, Olivier and Frasca, Loredana and Durr, Sophie and Conrad, Curdin and Schr¨oder, Jens and Gilliet, Michel (2015) Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self-DNA. European Journal of Immunology, 45 (1). pp. 203-213. |
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| Relation |
http://dx.doi.org/10.1002/eji.201344277
http://www.eprints.iicb.res.in/2215/ |
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