Isolation, structural elucidation and cytotoxicity evaluation of a new pentahydroxy-pimarane diterpenoid along with other chemical constituents from Aerva lanata
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Isolation, structural elucidation and cytotoxicity evaluation of a new pentahydroxy-pimarane diterpenoid along with other chemical constituents from Aerva lanata
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| Creator |
Bharitkar, Yogesh P
Hazra, Abhijit Poduri, N.S. Apoorva Ash, Anirban Maulik, Prakas R. Mondal, Nirup B |
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| Subject |
Chemistry
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| Description |
Aerva lanata possesses various useful medicinal and pharmaceutical activities.Phytochemical investigation of the plant has now led to the isolation of a new
2a,3a,15,16,19-pentahydroxy pimar-8(14)-ene diterpenoid (1) together with 12 other known compounds identified as b-sitosterol (2), b-sitosterol-3-O-b-D-glucoside (3),
canthin-6-one (4), 10-hydroxycanthin-6-one (aervine, 5), 10-methoxycanthin-6-one (methylaervine, 6), b-carboline-1-propionic acid (7), 1-O-b-D-glucopyranosyl- (2S,3R,8E)-2-[(20R)-2-hydroxylpalmitoylamino]-8-octadecene-1,3-diol (8), 1-O-(b-Dglucopyranosyl)-(2S,3S,4R,8Z)-2-[(20R)-20-hydroxytetracosanoylamino]-8(Z)-octadene-1,3,4-triol (9), (2S,3S,4R,10E)-2-[(20R)-20-hydroxytetracosanoylamino]-10-octadecene-1,3,4-triol (10), 60-O-(400-hydroxy-trans-cinnamoyl)-kaempferol-3-O-b-Dglucopyranoside
(tribuloside, 11), 3-cinnamoyltribuloside (12) and sulfonoquinovosyldiacylglyceride (13). Among these, six compounds (8–13) are reported for the first
time from this plant. Cytotoxicity evaluation of the compounds against five cancer cell lines (CHO, HepG2, HeLa, A-431 and MCF-7) shows promising IC50 values for
compounds 4, 6 and 12.
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| Publisher |
Taylor & Francis
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| Date |
2015
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2244/1/NATURAL_PRODUCT_RESEARCH__V._29___(_3__)_253%2D261_;2015[72].pdf
Bharitkar, Yogesh P and Hazra, Abhijit and Poduri, N.S. Apoorva and Ash, Anirban and Maulik, Prakas R. and Mondal, Nirup B (2015) Isolation, structural elucidation and cytotoxicity evaluation of a new pentahydroxy-pimarane diterpenoid along with other chemical constituents from Aerva lanata. Natural Product Research, 29 (3). pp. 253-261. ISSN 1478-6419 |
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| Relation |
http://dx.doi.org/10.1080/14786419.2014.971794
http://www.eprints.iicb.res.in/2244/ |
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