To be or not to be: The host genetic factor and beyond in Helicobacter pylori mediated gastro-duodenal diseases
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
To be or not to be: The host genetic factor and beyond in
Helicobacter pylori mediated gastro-duodenal diseases
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| Creator |
Datta De, Dipanjana
Roychoudhury, Susanta |
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| Subject |
Cancer Biology and Inflammatory Disorder Division
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| Description |
Helicobacter pylori (H. pylori ) have long been associated
with a spectrum of disease outcomes in the gastroduodenal
system. Heterogeneity in bacterial virulence
factors or strains is not enough to explain the divergent
disease phenotypes manifested by the infection.
This review focuses on host genetic factors that are
involved during infection and eventually are thought to
influence the disease phenotype. We have summarized the different host genes that have been investigated
for association studies in H. pylori mediated duodenal
ulcer or gastric cancer. We discuss that as the bacteria
co-evolved with the host; these host gene also show
much variation across different ethnic population.
We illustrate the allelic distribution of interleukin-1B,
across different population which is one of the most
popular candidate gene studied with respect to H.
pylori infections. Further, we highlight that several
polymorphisms in the pathway gene can by itself or
collectively affect the acid secretion pathway axis
(gastrin: somatostatin) thereby resulting in a spectrum
of disease phenotype
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| Date |
2015
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2256/1/WORLD_JOURNAL_OF_GASTROENTEROLOGY__V_21_(_10_)_2883%2D2895;2015[43].pdf
Datta De, Dipanjana and Roychoudhury, Susanta (2015) To be or not to be: The host genetic factor and beyond in Helicobacter pylori mediated gastro-duodenal diseases. World J Gastroenterol, 21 (10). pp. 2883-2895. |
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| Relation |
http://dx.doi.org/10.3748/wjg.v21.i10.2883
http://www.eprints.iicb.res.in/2256/ |
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