NAD(P)H Cytochrome b5 Oxidoreductase Deficiency in Leishmania major Results in Impaired Linoleate Synthesis Followed by Increased Oxidative Stress and Cell Death
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
NAD(P)H Cytochrome b5 Oxidoreductase Deficiency in
Leishmania major Results in Impaired Linoleate Synthesis
Followed by Increased Oxidative Stress and Cell Death
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| Creator |
Mukherjee, Supratim
Sen Santara, Sumit Das, Shantanabha Bose, Moumita Roy, Jayasree Adak, Subrata |
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| Subject |
Structural Biology & Bioinformatics
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| Description |
NAD(P)H cytochrome b5 oxidoreductase (Ncb5or) participates in a variety of metabolic conversions.
Results: A new Ncb5or acts as a redox partner of �12 fatty acid desaturase.
Conclusion: Ncb5or null mutant suffers from impaired linoleate synthesis leading to oxidative stress and cell death.
Significance: Our results have exposed a novel fatty acid synthesis pathway in L. major that differs from the mammalian
system.
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| Publisher |
American Society for Biochemistry and Molecular Biology
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| Date |
1991
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2292/1/JOURNAL_OF_BIOLOGICAL_CHEMISTRY__V._287_(_42_)34992%2D35003.pdf
Mukherjee, Supratim and Sen Santara, Sumit and Das, Shantanabha and Bose, Moumita and Roy, Jayasree and Adak, Subrata (1991) NAD(P)H Cytochrome b5 Oxidoreductase Deficiency in Leishmania major Results in Impaired Linoleate Synthesis Followed by Increased Oxidative Stress and Cell Death. The Journal of Biological Chemistry, 287 (42). pp. 34992-35003. |
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| Relation |
http://www.eprints.iicb.res.in/2292/
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